Technical Description of OBD-II Trouble Code
Issue with Cylinder 4 Contribution/Balance
What does that signify?
This diagnostic trouble code (DTC) is a generic powertrain code that is applicable to vehicles equipped with OBD-II. While it is a generic code, the specific repair steps may vary depending on the make and model of the vehicle.
The OBD II trouble code P0272 indicates a problem with cylinder number 4 contribution/balance. Essentially, this code indicates that there is a fuel-related issue with the fourth cylinder in the firing order.
This code is also generic, meaning it is common to all manufacturers. The reference is the same, but a specific model’s manufacturer may have encountered a defective part or an error during installation.
Always refer to the technical service bulletins (TSBs) online for your specific vehicle’s year and make. Look for related TSBs and follow the factory recommended repair procedure.
The powertrain control module (PCM) monitors the power output of each cylinder by comparing the acceleration or increase in speed of the crankshaft during the power stroke of each cylinder.
When one or more cylinders contribute less power than the rest, the fault code P0272 is triggered.
While the PCM performs this test to determine if a fuel injector is functioning properly, an auto technician can conduct a similar test to identify internal engine problems. By removing one spark plug at a time while the engine is running, the technician observes the RPM drop on each cylinder.
All cylinders should have a drop in RPM within 5 percent of each other. If a cylinder shows a lesser drop in RPM, it requires repair. Both tests compare crankshaft RPM.
This is a problem that should be addressed as soon as possible to prevent any potential damage.
Cross-section diagram of a typical automotive fuel injector (provided by WikipedianProlific):

Symptoms
The symptoms associated with a P0272 code may include:
Causes
In my experience, this code indicates a decrease in power produced by the number four cylinder. An electrical issue would trigger a code for either a high or low voltage situation for this injector.
A lack of fuel reaching the number four cylinder is the most probable cause. The injector may have completely failed or it may be releasing a small amount of fuel instead of the normal conical spray. This could be due to dirt or contamination of the inlet filter on the injector.